Discovery of a chemical probe for the L3MBTL3 methyl-lysine reader domain

We describe the discovery of UNC1215, a potent and selective chemical probe for the methyl-lysine (Kme) reading function of L3MBTL3, a member of the malignant brain tumor (MBT) family of chromatin interacting transcriptional repressors. UNC1215 binds L3MBTL3 with a K(d) of 120 nM, competitively disp...

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Detalles Bibliográficos
Autores principales: James, Lindsey I., Barsyte-Lovejoy, Dalia, Zhong, Nan, Krichevsky, Liubov, Korboukh, Victoria K., Herold, Martin J., MacNevin, Christopher J., Norris, Jacqueline L., Sagum, Cari A., Tempel, Wolfram, Marcon, Edyta, Guo, Hongbo, Gao, Cen, Huang, Xi-Ping, Duan, Shili, Emili, Andrew, Greenblatt, Jack F., Kireev, Dmitri B., Jin, Jian, Janzen, William P., Brown, Peter J., Bedford, Mark T., Arrowsmith, Cheryl H., Frye, Stephen V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577944/
https://www.ncbi.nlm.nih.gov/pubmed/23292653
http://dx.doi.org/10.1038/nchembio.1157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577944/
https://www.ncbi.nlm.nih.gov/pubmed/23292653
http://dx.doi.org/10.1038/nchembio.1157

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