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The Sequence of the Enterococcal Cytolysin Imparts Unusual Lanthionine Stereochemistry
The enterococcal cytolysin is a two-component lantibiotic of unknown structure with hemolytic activity that is important for virulence. We prepared cytolysin by co-expression of each precursor peptide with the synthetase CylM in E. coli, and characterized its structure. Surprisingly, cytolysin is th...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578037/ https://www.ncbi.nlm.nih.gov/pubmed/23314913 http://dx.doi.org/10.1038/nchembio.1162 |