Comparative Analysis of Four Oxidized Guanine Lesions from Reactions of DNA with Peroxynitrite, Singlet Oxygen, and γ-Radiation

[Image: see text] Oxidative damage to DNA has many origins, including irradiation, inflammation, and oxidative stress, but the chemistries are not the same. The most oxidizable base in DNA is 2-deoxyguanosine (dG), and the primary oxidation products are 8-oxodG and 2-amino-imidazolone. The latter ra...

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Detalles Bibliográficos
Autores principales: Cui, Liang, Ye, Wenjie, Prestwich, Erin G., Wishnok, John S., Taghizadeh, Koli, Dedon, Peter C., Tannenbaum, Steven R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578445/
https://www.ncbi.nlm.nih.gov/pubmed/23140136
http://dx.doi.org/10.1021/tx300294d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578445/
https://www.ncbi.nlm.nih.gov/pubmed/23140136
http://dx.doi.org/10.1021/tx300294d

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