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UCP2 Deficiency Helps to Restrict the Pathogenesis of Experimental Cutaneous and Visceral Leishmaniosis in Mice

BACKGROUND: Uncoupling protein 2 (UCP2) is a mitochondrial transporter that has been shown to lower the production of reactive oxygen species (ROS). Intracellular pathogens such as Leishmania upregulate UCP2 and thereby suppress ROS production in infected host tissues, allowing the multiplication of...

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Detalles Bibliográficos
Autores principales: Carrión, Javier, Abengozar, M. Angeles, Fernández-Reyes, María, Sánchez-Martín, Carlos, Rial, Eduardo, Domínguez-Bernal, Gustavo, González-Barroso, M. Mar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578745/
https://www.ncbi.nlm.nih.gov/pubmed/23437414
http://dx.doi.org/10.1371/journal.pntd.0002077