Random Codon Re-encoding Induces Stable Reduction of Replicative Fitness of Chikungunya Virus in Primate and Mosquito Cells

Large-scale codon re-encoding represents a powerful method of attenuating viruses to generate safe and cost-effective vaccines. In contrast to specific approaches of codon re-encoding which modify genome-scale properties, we evaluated the effects of random codon re-encoding on the re-emerging human...

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Detalles Bibliográficos
Autores principales: Nougairede, Antoine, De Fabritus, Lauriane, Aubry, Fabien, Gould, Ernest A., Holmes, Edward C., de Lamballerie, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578757/
https://www.ncbi.nlm.nih.gov/pubmed/23436995
http://dx.doi.org/10.1371/journal.ppat.1003172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578757/
https://www.ncbi.nlm.nih.gov/pubmed/23436995
http://dx.doi.org/10.1371/journal.ppat.1003172

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