Gene Expression and Thiopurine Metabolite Profiling in Inflammatory Bowel Disease – Novel Clues to Drug Targets and Disease Mechanisms?

BACKGROUND AND AIMS: Thiopurines are effective to induce and maintain remission in inflammatory bowel disease (IBD). The methyl thioinosine monophosphate (meTIMP)/6-thioguanine nucleotide (6-TGN) concentration ratio has been associated with drug efficacy. Here we explored the molecular basis of diff...

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Detalles Bibliográficos
Autores principales: Haglund, Sofie, Almer, Sven, Peterson, Curt, Söderman, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578787/
https://www.ncbi.nlm.nih.gov/pubmed/23437289
http://dx.doi.org/10.1371/journal.pone.0056989

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578787/
https://www.ncbi.nlm.nih.gov/pubmed/23437289
http://dx.doi.org/10.1371/journal.pone.0056989

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