Intracellular Bacillary Burden Reflects a Burst Size for Mycobacterium tuberculosis In Vivo

We previously reported that Mycobacterium tuberculosis triggers macrophage necrosis in vitro at a threshold intracellular load of ∼25 bacilli. This suggests a model for tuberculosis where bacilli invading lung macrophages at low multiplicity of infection proliferate to burst size and spread to naïve...

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Detalles Bibliográficos
Autores principales: Repasy, Teresa, Lee, Jinhee, Marino, Simeone, Martinez, Nuria, Kirschner, Denise E., Hendricks, Gregory, Baker, Stephen, Wilson, Andrew A., Kotton, Darrell N., Kornfeld, Hardy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578792/
https://www.ncbi.nlm.nih.gov/pubmed/23436998
http://dx.doi.org/10.1371/journal.ppat.1003190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578792/
https://www.ncbi.nlm.nih.gov/pubmed/23436998
http://dx.doi.org/10.1371/journal.ppat.1003190

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