Cargando…
Intracellular Bacillary Burden Reflects a Burst Size for Mycobacterium tuberculosis In Vivo
We previously reported that Mycobacterium tuberculosis triggers macrophage necrosis in vitro at a threshold intracellular load of ∼25 bacilli. This suggests a model for tuberculosis where bacilli invading lung macrophages at low multiplicity of infection proliferate to burst size and spread to naïve...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578792/ https://www.ncbi.nlm.nih.gov/pubmed/23436998 http://dx.doi.org/10.1371/journal.ppat.1003190 |