Induction of p16(INK4a) Is the Major Barrier to Proliferation when Epstein-Barr Virus (EBV) Transforms Primary B Cells into Lymphoblastoid Cell Lines

To explore the role of p16(INK4a) as an intrinsic barrier to B cell transformation by EBV, we transformed primary B cells from an individual homozygous for a deletion in the CDKN2A locus encoding p16(INK4a) and p14(ARF). Using recombinant EBV-BAC viruses expressing conditional EBNA3C (3CHT), we deve...

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Detalles Bibliográficos
Autores principales: Skalska, Lenka, White, Robert E., Parker, Gillian A., Sinclair, Alison J., Paschos, Kostas, Allday, Martin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578823/
https://www.ncbi.nlm.nih.gov/pubmed/23436997
http://dx.doi.org/10.1371/journal.ppat.1003187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578823/
https://www.ncbi.nlm.nih.gov/pubmed/23436997
http://dx.doi.org/10.1371/journal.ppat.1003187

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