Reactive Oxygen Species via Redox Signaling to PI3K/AKT Pathway Contribute to the Malignant Growth of 4-Hydroxy Estradiol-Transformed Mammary Epithelial Cells

The purpose of this study was to investigate the effects of 17-β-estradiol (E2)-induced reactive oxygen species (ROS) on the induction of mammary tumorigenesis. We found that ROS-induced by repeated exposures to 4-hydroxy-estradiol (4-OH-E2), a predominant catechol metabolite of E2, caused transform...

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Detalles Bibliográficos
Autores principales: Okoh, Victor O., Felty, Quentin, Parkash, Jai, Poppiti, Robert, Roy, Deodutta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578838/
https://www.ncbi.nlm.nih.gov/pubmed/23437041
http://dx.doi.org/10.1371/journal.pone.0054206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578838/
https://www.ncbi.nlm.nih.gov/pubmed/23437041
http://dx.doi.org/10.1371/journal.pone.0054206

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