BH3-Mimetics- and Cisplatin-Induced Cell Death Proceeds through Different Pathways Depending on the Availability of Death-Related Cellular Components

BACKGROUND: Owing to their important function in regulating cell death, pharmacological inhibition of Bcl-2 proteins by dubbed BH3-mimetics is a promising strategy for apoptosis induction or sensitization to chemotherapy. However, the role of Apaf-1, the main protein constituent of the apoptosome, i...

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Detalles Bibliográficos
Autores principales: Andreu-Fernández, Vicente, Genovés, Ainhoa, Messeguer, Angel, Orzáez, Mar, Sancho, Mónica, Pérez-Payá, Enrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578861/
https://www.ncbi.nlm.nih.gov/pubmed/23437261
http://dx.doi.org/10.1371/journal.pone.0056881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578861/
https://www.ncbi.nlm.nih.gov/pubmed/23437261
http://dx.doi.org/10.1371/journal.pone.0056881

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