Different Patterns of Akt and ERK Feedback Activation in Response to Rapamycin, Active-Site mTOR Inhibitors and Metformin in Pancreatic Cancer Cells

The mTOR pathway is aberrantly stimulated in many cancer cells, including pancreatic ductal adenocarcinoma (PDAC), and thus it is a potential target for therapy. However, the mTORC1/S6K axis also mediates negative feedback loops that attenuate signaling via insulin/IGF receptor and other tyrosine ki...

Descripción completa

Detalles Bibliográficos
Autores principales: Soares, Heloisa P., Ni, Yang, Kisfalvi, Krisztina, Sinnett-Smith, James, Rozengurt, Enrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578870/
https://www.ncbi.nlm.nih.gov/pubmed/23437362
http://dx.doi.org/10.1371/journal.pone.0057289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578870/
https://www.ncbi.nlm.nih.gov/pubmed/23437362
http://dx.doi.org/10.1371/journal.pone.0057289

Ejemplares similares