FoxO3a Directs a Protective Autophagy Program in Hematopoietic Stem Cells

Blood production is ensured by rare self-renewing hematopoietic stem cells (HSCs). How HSCs accommodate the diverse cellular stresses associated with their life-long activity remains elusive. Here, we identify autophagy as an essential mechanism protecting HSCs from metabolic stress. We show that HS...

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Detalles Bibliográficos
Autores principales: Warr, Matthew R., Binnewies, Mikhail, Flach, Johanna, Reynaud, Damien, Garg, Trit, Malhotra, Ritu, Debnath, Jayanta, Passegué, Emmanuelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579002/
https://www.ncbi.nlm.nih.gov/pubmed/23389440
http://dx.doi.org/10.1038/nature11895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579002/
https://www.ncbi.nlm.nih.gov/pubmed/23389440
http://dx.doi.org/10.1038/nature11895

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