Comparative Structural and Functional Studies of 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 Inhibitors Suggest the Basis for Isotype Selectivity

[Image: see text] Cyclin-dependent kinase 9/cyclin T, the protein kinase heterodimer that constitutes positive transcription elongation factor b, is a well-validated target for treatment of several diseases, including cancer and cardiac hypertrophy. In order to aid inhibitor design and rationalize t...

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Detalles Bibliográficos
Autores principales: Hole, Alison J., Baumli, Sonja, Shao, Hao, Shi, Shenhua, Huang, Shiliang, Pepper, Chris, Fischer, Peter M., Wang, Shudong, Endicott, Jane A., Noble, Martin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579457/
https://www.ncbi.nlm.nih.gov/pubmed/23252711
http://dx.doi.org/10.1021/jm301495v

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579457/
https://www.ncbi.nlm.nih.gov/pubmed/23252711
http://dx.doi.org/10.1021/jm301495v

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