In vivo functional brain mapping in a conditional mouse model of human tauopathy (tau(p301l)) reveals reduced neural activity in memory formation structures

BACKGROUND: Tauopathies are characterized by intracellular deposition of the microtubule-associated protein tau as filamentous aggregates. The rTg4510 mouse conditionally expresses mutant human tau protein in various forebrain areas under the Tet-off expression system. Mice develop neurofibrillary t...

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Detalles Bibliográficos
Autores principales: Perez, Pablo D, Hall, Gabrielle, Kimura, Tetsuya, Ren, Yan, Bailey, Rachel M, Lewis, Jada, Febo, Marcelo, Sahara, Naruhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579718/
https://www.ncbi.nlm.nih.gov/pubmed/23379588
http://dx.doi.org/10.1186/1750-1326-8-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579718/
https://www.ncbi.nlm.nih.gov/pubmed/23379588
http://dx.doi.org/10.1186/1750-1326-8-9

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