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In vivo functional brain mapping in a conditional mouse model of human tauopathy (tau(p301l)) reveals reduced neural activity in memory formation structures

BACKGROUND: Tauopathies are characterized by intracellular deposition of the microtubule-associated protein tau as filamentous aggregates. The rTg4510 mouse conditionally expresses mutant human tau protein in various forebrain areas under the Tet-off expression system. Mice develop neurofibrillary t...

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Detalles Bibliográficos
Autores principales:	Perez, Pablo D, Hall, Gabrielle, Kimura, Tetsuya, Ren, Yan, Bailey, Rachel M, Lewis, Jada, Febo, Marcelo, Sahara, Naruhiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579718/ https://www.ncbi.nlm.nih.gov/pubmed/23379588 http://dx.doi.org/10.1186/1750-1326-8-9

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