Loss of lkb1 Expression Reduces the Latency of ErbB2-Mediated Mammary Gland Tumorigenesis, Promoting Changes in Metabolic Pathways

The tumor suppressor kinase LKB1 is mutated in a broad range of cancers however, the role of LKB1 mammary gland tumorigenesis is not fully understood. Evaluation of human breast cancer tissue microarrays, indicate that 31% of HER2 positive samples lacked LKB1 expression. To expand on these observati...

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Detalles Bibliográficos
Autores principales: Andrade-Vieira, Rafaela, Xu, Zhaolin, Colp, Patricia, Marignani, Paola A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579833/
https://www.ncbi.nlm.nih.gov/pubmed/23451056
http://dx.doi.org/10.1371/journal.pone.0056567

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579833/
https://www.ncbi.nlm.nih.gov/pubmed/23451056
http://dx.doi.org/10.1371/journal.pone.0056567

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