Identification of a Small Molecule That Selectively Inhibits Mouse PC2 over Mouse PC1/3: A Computational and Experimental Study

The calcium-dependent serine endoproteases prohormone convertase 1/3 (PC1/3) and prohormone convertase 2 (PC2) play important roles in the homeostatic regulation of blood glucose levels, hence implicated in diabetes mellitus. Specifically, the absence of PC2 has been associated with chronic hypoglyc...

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Detalles Bibliográficos
Autores principales: Yongye, Austin B., Vivoli, Mirella, Lindberg, Iris, Appel, Jon R., Houghten, Richard A., Martinez-Mayorga, Karina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579927/
https://www.ncbi.nlm.nih.gov/pubmed/23451118
http://dx.doi.org/10.1371/journal.pone.0056957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579927/
https://www.ncbi.nlm.nih.gov/pubmed/23451118
http://dx.doi.org/10.1371/journal.pone.0056957

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