The action of selective CRAC channel blockers is affected by the Orai pore geometry

As the molecular composition of calcium-release activated calcium (CRAC) channels has been unknown for two decades, elucidation of selective inhibitors has been considerably hampered. By the identification of the two key components of CRAC channels, STIM1 and Orai1 have emerged as promising targets...

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Detalles Bibliográficos
Autores principales: Derler, Isabella, Schindl, Rainer, Fritsch, Reinhard, Heftberger, Peter, Riedl, Maria Christine, Begg, Malcolm, House, David, Romanin, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580291/
https://www.ncbi.nlm.nih.gov/pubmed/23218667
http://dx.doi.org/10.1016/j.ceca.2012.11.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580291/
https://www.ncbi.nlm.nih.gov/pubmed/23218667
http://dx.doi.org/10.1016/j.ceca.2012.11.005

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