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The action of selective CRAC channel blockers is affected by the Orai pore geometry
As the molecular composition of calcium-release activated calcium (CRAC) channels has been unknown for two decades, elucidation of selective inhibitors has been considerably hampered. By the identification of the two key components of CRAC channels, STIM1 and Orai1 have emerged as promising targets...
Autores principales: | Derler, Isabella, Schindl, Rainer, Fritsch, Reinhard, Heftberger, Peter, Riedl, Maria Christine, Begg, Malcolm, House, David, Romanin, Christoph |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580291/ https://www.ncbi.nlm.nih.gov/pubmed/23218667 http://dx.doi.org/10.1016/j.ceca.2012.11.005 |
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