Matrilin-3 Induction of IL-1 receptor antagonist Is required for up-regulating collagen II and aggrecan and down-regulating ADAMTS-5 gene expression

INTRODUCTION: Deletion or mutation of the gene encoding the cartilage extracellular matrix (ECM) protein matrilin-3 (MATN3) results in the early onset of osteoarthritis (OA), suggesting chondroprotective properties of MATN3. To understand the mechanisms underlying these properties, we determined the...

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Detalles Bibliográficos
Autores principales: Jayasuriya, Chathuraka T, Goldring, Mary B, Terek, Richard, Chen, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580507/
https://www.ncbi.nlm.nih.gov/pubmed/22967398
http://dx.doi.org/10.1186/ar4033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580507/
https://www.ncbi.nlm.nih.gov/pubmed/22967398
http://dx.doi.org/10.1186/ar4033

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