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Polymorphisms in cytochrome P450 2C19 enzyme and cessation of leflunomide in patients with rheumatoid arthritis

INTRODUCTION: Rational selection of disease modifying anti-rheumatic drugs in the treatment of rheumatoid arthritis (RA) has many potential advantages, including rapid disease control, reduced long-term disability and reduced overall cost to the healthcare system. Inter-individual genetic difference...

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Detalles Bibliográficos
Autores principales: Wiese, Michael D, Schnabl, Matthew, O'Doherty, Catherine, Spargo, Llewellyn D, Sorich, Michael J, Cleland, Leslie G, Proudman, Susanna M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580556/
https://www.ncbi.nlm.nih.gov/pubmed/22784880
http://dx.doi.org/10.1186/ar3911