Cargando…
Inhibition of Carnitine Palmitoyltransferase-1 Activity Alleviates Insulin Resistance in Diet-Induced Obese Mice
Impaired skeletal muscle fatty acid oxidation has been suggested to contribute to insulin resistance and glucose intolerance. However, increasing muscle fatty acid oxidation may cause a reciprocal decrease in glucose oxidation, which might impair insulin sensitivity and glucose tolerance. We therefo...
Autores principales: | Keung, Wendy, Ussher, John R., Jaswal, Jagdip S., Raubenheimer, Monique, Lam, Victoria H.M., Wagg, Cory S., Lopaschuk, Gary D. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581198/ https://www.ncbi.nlm.nih.gov/pubmed/23139350 http://dx.doi.org/10.2337/db12-0259 |
Ejemplares similares
-
Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption
por: Ussher, John R., et al.
Publicado: (2010) -
Overexpression of Carnitine Palmitoyltransferase-1 in Skeletal Muscle Is Sufficient to Enhance Fatty Acid Oxidation and Improve High-Fat Diet–Induced Insulin Resistance
por: Bruce, Clinton R., et al.
Publicado: (2009) -
Inhibition of Serine Palmitoyl Transferase I Reduces Cardiac Ceramide Levels and Increases Glycolysis Rates following Diet-Induced Insulin Resistance
por: Ussher, John R., et al.
Publicado: (2012) -
Insulin-Stimulated Cardiac Glucose Oxidation Is Increased in High-Fat Diet–Induced Obese Mice Lacking Malonyl CoA Decarboxylase
por: Ussher, John R., et al.
Publicado: (2009) -
Carnitine Palmitoyltransferase 1b Deficiency Protects Mice from Diet-Induced Insulin Resistance
por: Kim, Teayoun, et al.
Publicado: (2014)