C-Reactive Protein Causes Insulin Resistance in Mice Through Fcγ Receptor IIB–Mediated Inhibition of Skeletal Muscle Glucose Delivery

Elevations in C-reactive protein (CRP) are associated with an increased risk of insulin resistance. Whether CRP plays a causal role is unknown. Here we show that CRP transgenic mice and wild-type mice administered recombinant CRP are insulin resistant. Mice lacking the inhibitory Fcγ receptor IIB (F...

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Detalles Bibliográficos
Autores principales: Tanigaki, Keiji, Vongpatanasin, Wanpen, Barrera, Jose A., Atochin, Dmitriy N., Huang, Paul L., Bonvini, Ezio, Shaul, Philip W., Mineo, Chieko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581204/
https://www.ncbi.nlm.nih.gov/pubmed/23069625
http://dx.doi.org/10.2337/db12-0133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581204/
https://www.ncbi.nlm.nih.gov/pubmed/23069625
http://dx.doi.org/10.2337/db12-0133

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