Fenretinide Treatment Prevents Diet-Induced Obesity in Association With Major Alterations in Retinoid Homeostatic Gene Expression in Adipose, Liver, and Hypothalamus

The synthetic retinoid, Fenretinide (FEN), inhibits obesity and insulin resistance in mice and is in early clinical trials for treatment of insulin resistance in obese humans. We aimed to determine whether alterations in retinoic acid (RA)-responsive genes contribute to the beneficial effects of FEN...

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Detalles Bibliográficos
Autores principales: Mcilroy, George D., Delibegovic, Mirela, Owen, Carl, Stoney, Patrick N., Shearer, Kirsty D., McCaffery, Peter J., Mody, Nimesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Obesity Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581207/
https://www.ncbi.nlm.nih.gov/pubmed/23193184
http://dx.doi.org/10.2337/db12-0458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581207/
https://www.ncbi.nlm.nih.gov/pubmed/23193184
http://dx.doi.org/10.2337/db12-0458

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