The Wnt Signaling Pathway Effector TCF7L2 Controls Gut and Brain Proglucagon Gene Expression and Glucose Homeostasis

The type 2 diabetes risk gene TCF7L2 is the effector of the Wnt signaling pathway. We found previously that in gut endocrine L-cell lines, TCF7L2 controls transcription of the proglucagon gene (gcg), which encodes the incretin hormone glucagon-like peptide-1 (GLP-1). Whereas peripheral GLP-1 stimula...

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Detalles Bibliográficos
Autores principales: Shao, Weijuan, Wang, Dingyan, Chiang, Yu-Ting, Ip, Wilfred, Zhu, Lingyun, Xu, Fenghao, Columbus, Joshua, Belsham, Denise D., Irwin, David M., Zhang, Haibo, Wen, Xiaoyan, Wang, Qinghua, Jin, Tianru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581223/
https://www.ncbi.nlm.nih.gov/pubmed/22966074
http://dx.doi.org/10.2337/db12-0365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581223/
https://www.ncbi.nlm.nih.gov/pubmed/22966074
http://dx.doi.org/10.2337/db12-0365

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