Cell-Based Screening Identifies Paroxetine as an Inhibitor of Diabetic Endothelial Dysfunction

We have conducted a phenotypic screening in endothelial cells exposed to elevated extracellular glucose (an in vitro model of hyperglycemia) to identify compounds that prevent hyperglycemia-induced reactive oxygen species (ROS) formation without adversely affecting cell viability. From a focused lib...

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Detalles Bibliográficos
Autores principales: Gerö, Domokos, Szoleczky, Petra, Suzuki, Kunihiro, Módis, Katalin, Oláh, Gabor, Coletta, Ciro, Szabo, Csaba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Complications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581231/
https://www.ncbi.nlm.nih.gov/pubmed/23223176
http://dx.doi.org/10.2337/db12-0789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581231/
https://www.ncbi.nlm.nih.gov/pubmed/23223176
http://dx.doi.org/10.2337/db12-0789

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