Caspase-2 Is Upregulated after Sciatic Nerve Transection and Its Inhibition Protects Dorsal Root Ganglion Neurons from Apoptosis after Serum Withdrawal

Sciatic nerve (SN) transection-induced apoptosis of dorsal root ganglion neurons (DRGN) is one factor determining the efficacy of peripheral axonal regeneration and the return of sensation. Here, we tested the hypothesis that caspase-2 (CASP2) orchestrates apoptosis of axotomised DRGN both in vivo a...

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Detalles Bibliográficos
Autores principales: Vigneswara, Vasanthy, Berry, Martin, Logan, Ann, Ahmed, Zubair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581492/
https://www.ncbi.nlm.nih.gov/pubmed/23451279
http://dx.doi.org/10.1371/journal.pone.0057861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581492/
https://www.ncbi.nlm.nih.gov/pubmed/23451279
http://dx.doi.org/10.1371/journal.pone.0057861

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