Structure of the Arginine Methyltransferase PRMT5-MEP50 Reveals a Mechanism for Substrate Specificity

The arginine methyltransferase PRMT5-MEP50 is required for embryogenesis and is misregulated in many cancers. PRMT5 targets a wide variety of substrates, including histone proteins involved in specifying an epigenetic code. However, the mechanism by which PRMT5 utilizes MEP50 to discriminate substra...

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Detalles Bibliográficos
Autores principales: Ho, Meng-Chiao, Wilczek, Carola, Bonanno, Jeffrey B., Xing, Li, Seznec, Janina, Matsui, Tsutomu, Carter, Lester G., Onikubo, Takashi, Kumar, P. Rajesh, Chan, Man K., Brenowitz, Michael, Cheng, R. Holland, Reimer, Ulf, Almo, Steven C., Shechter, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581573/
https://www.ncbi.nlm.nih.gov/pubmed/23451136
http://dx.doi.org/10.1371/journal.pone.0057008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581573/
https://www.ncbi.nlm.nih.gov/pubmed/23451136
http://dx.doi.org/10.1371/journal.pone.0057008

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