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MHC Class I-Restricted Myelin Epitopes Are Cross-Presented by Tip-DCs That Promote Determinant Spreading to CD8(+) T Cells
Myelin presentation to T cells within the central nervous system (CNS) sustains inflammation in multiple sclerosis (MS). CD4(+) and CD8(+) T cells contribute to MS; however, only cells that present myelin to CD4(+) T cells have been identified. We show that MHC class I-restricted myelin basic protei...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581685/ https://www.ncbi.nlm.nih.gov/pubmed/23291597 http://dx.doi.org/10.1038/ni.2513 |