The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state

Voltage-gated potassium (Kv) and sodium (Nav) channels are key determinants of cellular excitability and serve as targets of neurotoxins. Most marine ciguatoxins potentiate Nav channels and cause ciguatera seafood poisoning. Several ciguatoxins have also been shown to affect Kv channels, and we show...

Descripción completa

Detalles Bibliográficos
Autores principales: Kopljar, Ivan, Labro, Alain J., de Block, Tessa, Rainier, Jon D., Tytgat, Jan, Snyders, Dirk J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581691/
https://www.ncbi.nlm.nih.gov/pubmed/23401573
http://dx.doi.org/10.1085/jgp.201210890

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581691/
https://www.ncbi.nlm.nih.gov/pubmed/23401573
http://dx.doi.org/10.1085/jgp.201210890

Ejemplares similares