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The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state
Voltage-gated potassium (Kv) and sodium (Nav) channels are key determinants of cellular excitability and serve as targets of neurotoxins. Most marine ciguatoxins potentiate Nav channels and cause ciguatera seafood poisoning. Several ciguatoxins have also been shown to affect Kv channels, and we show...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581691/ https://www.ncbi.nlm.nih.gov/pubmed/23401573 http://dx.doi.org/10.1085/jgp.201210890 |