Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels II: A periodic paralysis mutation in Na(V)1.4 (L689I)

In skeletal muscle, slow inactivation (SI) of Na(V)1.4 voltage-gated sodium channels prevents spontaneous depolarization and fatigue. Inherited mutations in Na(V)1.4 that impair SI disrupt activity-induced regulation of channel availability and predispose patients to hyperkalemic periodic paralysis....

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Detalles Bibliográficos
Autores principales: Silva, Jonathan R., Goldstein, Steve A.N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581693/
https://www.ncbi.nlm.nih.gov/pubmed/23401572
http://dx.doi.org/10.1085/jgp.201210910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581693/
https://www.ncbi.nlm.nih.gov/pubmed/23401572
http://dx.doi.org/10.1085/jgp.201210910

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