Cargando…

The voltage-sensing domain of a phosphatase gates the pore of a potassium channel

The modular architecture of voltage-gated K(+) (Kv) channels suggests that they resulted from the fusion of a voltage-sensing domain (VSD) to a pore module. Here, we show that the VSD of Ciona intestinalis phosphatase (Ci-VSP) fused to the viral channel Kcv creates Kv(Synth1), a functional voltage-g...

Descripción completa

Detalles Bibliográficos
Autores principales: Arrigoni, Cristina, Schroeder, Indra, Romani, Giulia, Van Etten, James L., Thiel, Gerhard, Moroni, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581695/
https://www.ncbi.nlm.nih.gov/pubmed/23440279
http://dx.doi.org/10.1085/jgp.201210940