Diabetes and Risk of Cancer

Diabetes and cancer represent two complex, diverse, chronic, and potentially fatal diseases. Cancer is the second leading cause of death, while diabetes is the seventh leading cause of death with the latter still likely underreported. There is a growing body of evidence published in recent years tha...

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Autores principales: Habib, Samy L., Rojna, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582053/
https://www.ncbi.nlm.nih.gov/pubmed/23476808
http://dx.doi.org/10.1155/2013/583786
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author Habib, Samy L.
Rojna, Maciej
author_facet Habib, Samy L.
Rojna, Maciej
author_sort Habib, Samy L.
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description Diabetes and cancer represent two complex, diverse, chronic, and potentially fatal diseases. Cancer is the second leading cause of death, while diabetes is the seventh leading cause of death with the latter still likely underreported. There is a growing body of evidence published in recent years that suggest substantial increase in cancer incidence in diabetic patients. The worldwide prevalence of diabetes was estimated to rise from 171 million in 2000 to 366 million in 2030. About 26.9% of all people over 65 have diabetes and 60% have cancer. Overall, 8–18% of cancer patients have diabetes. In the context of epidemiology, the burden of both diseases, small association between diabetes and cancer will be clinically relevant and should translate into significant consequences for future health care solutions. This paper summarizes most of the epidemiological association studies between diabetes and cancer including studies relating to the general all-site increase of malignancies in diabetes and elevated organ-specific cancer rate in diabetes as comorbidity. Additionally, we have discussed the possible pathophysiological mechanisms that likely may be involved in promoting carcinogenesis in diabetes and the potential of different antidiabetic therapies to influence cancer incidence.
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spelling pubmed-35820532013-03-09 Diabetes and Risk of Cancer Habib, Samy L. Rojna, Maciej ISRN Oncol Review Article Diabetes and cancer represent two complex, diverse, chronic, and potentially fatal diseases. Cancer is the second leading cause of death, while diabetes is the seventh leading cause of death with the latter still likely underreported. There is a growing body of evidence published in recent years that suggest substantial increase in cancer incidence in diabetic patients. The worldwide prevalence of diabetes was estimated to rise from 171 million in 2000 to 366 million in 2030. About 26.9% of all people over 65 have diabetes and 60% have cancer. Overall, 8–18% of cancer patients have diabetes. In the context of epidemiology, the burden of both diseases, small association between diabetes and cancer will be clinically relevant and should translate into significant consequences for future health care solutions. This paper summarizes most of the epidemiological association studies between diabetes and cancer including studies relating to the general all-site increase of malignancies in diabetes and elevated organ-specific cancer rate in diabetes as comorbidity. Additionally, we have discussed the possible pathophysiological mechanisms that likely may be involved in promoting carcinogenesis in diabetes and the potential of different antidiabetic therapies to influence cancer incidence. Hindawi Publishing Corporation 2013-02-07 /pmc/articles/PMC3582053/ /pubmed/23476808 http://dx.doi.org/10.1155/2013/583786 Text en Copyright © 2013 S. L. Habib and M. Rojna. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Habib, Samy L.
Rojna, Maciej
Diabetes and Risk of Cancer
title Diabetes and Risk of Cancer
title_full Diabetes and Risk of Cancer
title_fullStr Diabetes and Risk of Cancer
title_full_unstemmed Diabetes and Risk of Cancer
title_short Diabetes and Risk of Cancer
title_sort diabetes and risk of cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582053/
https://www.ncbi.nlm.nih.gov/pubmed/23476808
http://dx.doi.org/10.1155/2013/583786
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