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Antiresorptive Activity of Bacillus-Fermented Antler Extracts: Inhibition of Osteoclast Differentiation
Antlers have been traditionally used for thousands of years as a natural product with medicinal and pharmaceutical properties. In developing healthy foods, Bacillus-mediated fermentation is widely used to enhance the biological activity of nutrients in foods. Recently, fermentation was shown to enha...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582071/ https://www.ncbi.nlm.nih.gov/pubmed/23509596 http://dx.doi.org/10.1155/2013/748687 |
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author | Choi, Sik-Won Moon, Seong-Hee Yang, Hye Jeong Kwon, Dae Young Son, Young-Jin Yu, Ri Kim, Young Su Kim, So I. Chae, Eun Jeong Park, Sang-Joon Kim, Seong Hwan |
author_facet | Choi, Sik-Won Moon, Seong-Hee Yang, Hye Jeong Kwon, Dae Young Son, Young-Jin Yu, Ri Kim, Young Su Kim, So I. Chae, Eun Jeong Park, Sang-Joon Kim, Seong Hwan |
author_sort | Choi, Sik-Won |
collection | PubMed |
description | Antlers have been traditionally used for thousands of years as a natural product with medicinal and pharmaceutical properties. In developing healthy foods, Bacillus-mediated fermentation is widely used to enhance the biological activity of nutrients in foods. Recently, fermentation was shown to enhance the osteogenic activity of antlers. This study aimed to elucidate the antiresorptive activity of Bacillus-fermented antler and its mode of action. We found that Bacillus-fermented antler extract strongly inhibited osteoclast differentiation by downregulating the expression and activity of nuclear factor of activated T cells, cytoplasmic 1 (NFATc1). This extract also inhibited the activation of phospholipase Cγ2 (PLCγ2), a signaling molecule that could regulate NFATc1 transcriptional activity. This suggested that Bacillus-fermented antler extract could inhibit PLCγ2-NFATc1 signaling required for bone resorption and cell fusion. Consequently, Bacillus-fermented antler extract might benefit osteoclast-related disorders, including osteoporosis; furthermore, it may improve gastrointestinal activity. |
format | Online Article Text |
id | pubmed-3582071 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35820712013-03-18 Antiresorptive Activity of Bacillus-Fermented Antler Extracts: Inhibition of Osteoclast Differentiation Choi, Sik-Won Moon, Seong-Hee Yang, Hye Jeong Kwon, Dae Young Son, Young-Jin Yu, Ri Kim, Young Su Kim, So I. Chae, Eun Jeong Park, Sang-Joon Kim, Seong Hwan Evid Based Complement Alternat Med Research Article Antlers have been traditionally used for thousands of years as a natural product with medicinal and pharmaceutical properties. In developing healthy foods, Bacillus-mediated fermentation is widely used to enhance the biological activity of nutrients in foods. Recently, fermentation was shown to enhance the osteogenic activity of antlers. This study aimed to elucidate the antiresorptive activity of Bacillus-fermented antler and its mode of action. We found that Bacillus-fermented antler extract strongly inhibited osteoclast differentiation by downregulating the expression and activity of nuclear factor of activated T cells, cytoplasmic 1 (NFATc1). This extract also inhibited the activation of phospholipase Cγ2 (PLCγ2), a signaling molecule that could regulate NFATc1 transcriptional activity. This suggested that Bacillus-fermented antler extract could inhibit PLCγ2-NFATc1 signaling required for bone resorption and cell fusion. Consequently, Bacillus-fermented antler extract might benefit osteoclast-related disorders, including osteoporosis; furthermore, it may improve gastrointestinal activity. Hindawi Publishing Corporation 2013 2013-02-10 /pmc/articles/PMC3582071/ /pubmed/23509596 http://dx.doi.org/10.1155/2013/748687 Text en Copyright © 2013 Sik-Won Choi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Choi, Sik-Won Moon, Seong-Hee Yang, Hye Jeong Kwon, Dae Young Son, Young-Jin Yu, Ri Kim, Young Su Kim, So I. Chae, Eun Jeong Park, Sang-Joon Kim, Seong Hwan Antiresorptive Activity of Bacillus-Fermented Antler Extracts: Inhibition of Osteoclast Differentiation |
title | Antiresorptive Activity of Bacillus-Fermented Antler Extracts: Inhibition of Osteoclast Differentiation |
title_full | Antiresorptive Activity of Bacillus-Fermented Antler Extracts: Inhibition of Osteoclast Differentiation |
title_fullStr | Antiresorptive Activity of Bacillus-Fermented Antler Extracts: Inhibition of Osteoclast Differentiation |
title_full_unstemmed | Antiresorptive Activity of Bacillus-Fermented Antler Extracts: Inhibition of Osteoclast Differentiation |
title_short | Antiresorptive Activity of Bacillus-Fermented Antler Extracts: Inhibition of Osteoclast Differentiation |
title_sort | antiresorptive activity of bacillus-fermented antler extracts: inhibition of osteoclast differentiation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582071/ https://www.ncbi.nlm.nih.gov/pubmed/23509596 http://dx.doi.org/10.1155/2013/748687 |
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