Application of a Novel Microtitre Plate-Based Assay for the Discovery of New Inhibitors of DNA Gyrase and DNA Topoisomerase VI

DNA topoisomerases are highly exploited targets for antimicrobial drugs. The spread of antibiotic resistance represents a significant threat to public health and necessitates the discovery of inhibitors that target topoisomerases in novel ways. However, the traditional assays for topoisomerase activ...

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Detalles Bibliográficos
Autores principales: Taylor, James A., Mitchenall, Lesley A., Rejzek, Martin, Field, Robert A., Maxwell, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582512/
https://www.ncbi.nlm.nih.gov/pubmed/23469129
http://dx.doi.org/10.1371/journal.pone.0058010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582512/
https://www.ncbi.nlm.nih.gov/pubmed/23469129
http://dx.doi.org/10.1371/journal.pone.0058010

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