Cargando…

Application of a Novel Microtitre Plate-Based Assay for the Discovery of New Inhibitors of DNA Gyrase and DNA Topoisomerase VI

DNA topoisomerases are highly exploited targets for antimicrobial drugs. The spread of antibiotic resistance represents a significant threat to public health and necessitates the discovery of inhibitors that target topoisomerases in novel ways. However, the traditional assays for topoisomerase activ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Taylor, James A., Mitchenall, Lesley A., Rejzek, Martin, Field, Robert A., Maxwell, Anthony
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582512/ https://www.ncbi.nlm.nih.gov/pubmed/23469129 http://dx.doi.org/10.1371/journal.pone.0058010

Ejemplares similares

High-throughput assays for DNA gyrase and other topoisomerases
por: Maxwell, Anthony, et al.
Publicado: (2006)

The role of Ca(2+) in the activity of Mycobacterium tuberculosis DNA gyrase
por: Karkare, Shantanu, et al.
Publicado: (2012)

Vibrio cholerae ParE2 Poisons DNA Gyrase via a Mechanism Distinct from Other Gyrase Inhibitors
por: Yuan, Jie, et al.
Publicado: (2010)

DNA Gyrase Is the Target for the Quinolone Drug Ciprofloxacin in Arabidopsis thaliana
por: Evans-Roberts, Katherine M., et al.
Publicado: (2016)

Creating tissue on chip constructs in microtitre plates for drug discovery
por: Macdonald, N. P., et al.
Publicado: (2018)

The Naphthoquinone Diospyrin Is an Inhibitor of DNA Gyrase with a Novel Mechanism of Action
por: Karkare, Shantanu, et al.
Publicado: (2013)

DNA G-segment bending is not the sole determinant of topology simplification by type II DNA topoisomerases
por: Thomson, Neil H., et al.
Publicado: (2014)

The pentapeptide-repeat protein, MfpA, interacts with mycobacterial DNA gyrase as a DNA T-segment mimic
por: Feng, Lipeng, et al.
Publicado: (2021)

Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase
por: Henderson, Sara R, et al.
Publicado: (2020)

Activities of gyrase and topoisomerase IV on positively supercoiled DNA
por: Ashley, Rachel E., et al.
Publicado: (2017)

Single-molecule imaging of DNA gyrase activity in living Escherichia coli
por: Stracy, Mathew, et al.
Publicado: (2019)

Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV
por: Grossman, Scott, et al.
Publicado: (2023)

Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV
por: Pitts, Steven L., et al.
Publicado: (2011)

Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by Gram-negative and Gram-positive type II DNA topoisomerases
por: Richter, Sara N., et al.
Publicado: (2007)

Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase
por: Ahmed, Wareed, et al.
Publicado: (2017)

Topoisomerase VI is a chirally-selective, preferential DNA decatenase
por: McKie, Shannon J, et al.
Publicado: (2022)

Structural insight into negative DNA supercoiling by DNA gyrase, a bacterial type 2A DNA topoisomerase
por: Papillon, Julie, et al.
Publicado: (2013)

Actions of a Novel Bacterial Topoisomerase Inhibitor against Neisseria gonorrhoeae Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks
por: Dauda, Soziema E., et al.
Publicado: (2023)

Novel Bacterial Topoisomerase Inhibitors Exploit Asp83 and the Intrinsic Flexibility of the DNA Gyrase Binding Site
por: Franco-Ulloa, Sebastian, et al.
Publicado: (2018)

Design, Synthesis, and Antibacterial Screening of Some Novel Heteroaryl-Based Ciprofloxacin Derivatives as DNA Gyrase and Topoisomerase IV Inhibitors
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2021)

Thickness of the aqueous boundary layer in stirred microtitre plate permeability assays (PAMPA and Caco-2), based on the Levich equation
por: Avdeef, Alex
Publicado: (2022)

DNA Gyrase and Topoisomerase IV Mutations and their effect on Quinolones Resistant Proteus mirabilis among UTIs Patients
por: Abdelkreem, Randa H, et al.
Publicado: (2020)

Automatic Microtitrator for Small Volume Samples
por: Wu, Zhizhen, et al.
Publicado: (2022)

Microtitration of Rubella Virus in Monovalent Vaccinal Products
por: Esna-Ashari, F, et al.
Publicado: (2011)

Discovery of a Novel DNA Gyrase-Targeting Antibiotic through the Chemical Perturbation of Streptomyces venezuelae Sporulation
por: McAuley, Scott, et al.
Publicado: (2019)

The role of monovalent cations in the ATPase reaction of DNA gyrase
por: Hearnshaw, Stephen James, et al.
Publicado: (2015)

Microtitre plate-based antibacterial assay incorporating resazurin as an indicator of cell growth, and its application in the in vitro antibacterial screening of phytochemicals
por: Sarker, Satyajit D., et al.
Publicado: (2007)

Resazurin microtitre plate assay and Sensititre® MycoTB for detection of Mycobacterium tuberculosis resistance in a high tuberculosis resistance setting
por: Jaglal, Prenika, et al.
Publicado: (2019)

Functional Analyses of the Toxoplasma gondii DNA Gyrase Holoenzyme: A Janus Topoisomerase with Supercoiling and Decatenation Abilities
por: Lin, Ting-Yu, et al.
Publicado: (2015)

Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors
por: Skok, Žiga, et al.
Publicado: (2020)

Discovery of Novel Inhibitors of Bacterial DNA Gyrase Using a QSAR-Based Approach
por: Jakhar, Ritu, et al.
Publicado: (2022)

DNA Topoisomerase Inhibitors: Trapping a DNA-Cleaving Machine in Motion
por: Bax, Benjamin D., et al.
Publicado: (2019)

Exploiting bacterial DNA gyrase as a drug target: current state and perspectives
por: Collin, Frédéric, et al.
Publicado: (2011)

A monoclonal antibody that inhibits mycobacterial DNA gyrase by a novel mechanism
por: Manjunatha, Ujjini H., et al.
Publicado: (2005)

Direct observation of helicase–topoisomerase coupling within reverse gyrase
por: Yang, Xi, et al.
Publicado: (2020)

Characterization of Mutations in DNA Gyrase and Topoisomerase IV in Field Strains and In Vitro Selected Quinolone-Resistant Mycoplasma hyorhinis Mutants
por: Li, Jun, et al.
Publicado: (2022)

Large Scale Screening of Southern African Plant Extracts for the Green Synthesis of Gold Nanoparticles Using Microtitre-Plate Method
por: Elbagory, Abdulrahman M., et al.
Publicado: (2016)

Solution structures of DNA-bound gyrase
por: Baker, Nicole M., et al.
Publicado: (2011)

DNA Gyrase as a Target for Quinolones
por: Spencer, Angela C., et al.
Publicado: (2023)

Arabidopsis thaliana GYRB3 Does Not Encode a DNA Gyrase Subunit
por: Evans-Roberts, Katherine M., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_s0m9ousud5keu9rm7ikveldgce