Analysis of the relationship between end-to-end distance and activity of single-chain antibody against colorectal carcinoma

We investigated the relationship of End-to-end distance between VH and VL with different peptide linkers and the activity of single-chain antibodies by computer-aided simulation. First, we developed (G(4)S)(n) (where n = 1-9) as the linker to connect VH and VL, and estimated the 3D structure of sing...

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Detalles Bibliográficos
Autores principales: Zhang, Jianhua, Liu, Shanhong, Shang, Zhigang, Shi, Li, Yun, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582594/
https://www.ncbi.nlm.nih.gov/pubmed/22913623
http://dx.doi.org/10.1186/1742-4682-9-38

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582594/
https://www.ncbi.nlm.nih.gov/pubmed/22913623
http://dx.doi.org/10.1186/1742-4682-9-38

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