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Continuous inhibition of epidermal growth factor receptor phosphorylation by erlotinib enhances antitumor activity of chemotherapy in erlotinib-resistant tumor xenografts

Erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, has been shown to have benefits for non-small cell lung cancer and pancreatic cancer patients; however, almost all patients develop progressive disease during the therapy. On the other hand, it has been reported that a tumor c...

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Detalles Bibliográficos
Autores principales: IWAI, TOSHIKI, MORIYA, YOICHIRO, SHIRANE, MASATOSHI, FUJIMOTO-OUCHI, KAORI, MORI, KAZUSHIGE
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583539/
https://www.ncbi.nlm.nih.gov/pubmed/22209766
http://dx.doi.org/10.3892/or.2011.1614