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Valproic acid overcomes hypoxia-induced resistance to apoptosis

Valproic acid (VPA), a histone deacetylase inhibitor (HDACi), has been shown to be an effective tool in cancer treatment. Although its ability to induce apoptosis has been described in many cancer types, the data come from experiments performed in normoxic (21% O(2)) conditions only. Therefore, we q...

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Detalles Bibliográficos
Autores principales: CIPRO, ŠIMON, HŘEBAČKOVÁ, JANA, HRABĚTA, JAN, POLJAKOVÁ, JITKA, ECKSCHLAGER, TOMÁŠ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583540/
https://www.ncbi.nlm.nih.gov/pubmed/22159638
http://dx.doi.org/10.3892/or.2011.1577