Cargando…

MG132, a proteasome inhibitor, induces human pulmonary fibroblast cell death via increasing ROS levels and GSH depletion

MG132 as a proteasome inhibitor can induce apoptotic cell death in lung cancer cells. However, little is known about the toxicological cellular effects of MG132 on normal primary lung cells. Here, we investigated the effects of N-acetyl cysteine (NAC) and vitamin C (well known antioxidants) or L-but...

Descripción completa

Detalles Bibliográficos
Autores principales:	PARK, WOO HYUN, KIM, SUHN HEE
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2012
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583605/ https://www.ncbi.nlm.nih.gov/pubmed/22266922 http://dx.doi.org/10.3892/or.2012.1642

Ejemplares similares

The proteasomal inhibitor MG132 prevents muscular dystrophy in zebrafish
por: Winder, Steve J, et al.
Publicado: (2011)

Proteasome inhibitor MG-132 induces MCPIP1 expression
por: Skalniak, Lukasz, et al.
Publicado: (2013)

Effects of proteasome inhibitor MG-132 on the parasite Schistosoma mansoni
por: Morais, Enyara R., et al.
Publicado: (2017)

Systemic Perturbation of the ERK Signaling Pathway by the Proteasome Inhibitor, MG132
por: Cirit, Murat, et al.
Publicado: (2012)

Proteasome inhibitor MG132 inhibits the process of renal interstitial fibrosis
por: Han, Lin, et al.
Publicado: (2019)

Stability of Zinc Finger Nuclease Protein Is Enhanced by the Proteasome Inhibitor MG132
por: Ramakrishna, Suresh, et al.
Publicado: (2013)

Anti-Cancer Effects of Auranofin in Human Lung Cancer Cells by Increasing Intracellular ROS Levels and Depleting GSH Levels
por: Cui, Xia Ying, et al.
Publicado: (2022)

Systemic Analysis of Heat Shock Response Induced by Heat Shock and a Proteasome Inhibitor MG132
por: Kim, Hee-Jung, et al.
Publicado: (2011)

The proteasome inhibitor MG132 reduces immobilization-induced skeletal muscle atrophy in mice
por: Caron, Annabelle Z, et al.
Publicado: (2011)

Proteasome inhibitor MG132 enhances the sensitivity of human OSCC cells to cisplatin via a ROS/DNA damage/p53 axis
por: Zheng, Zheng, et al.
Publicado: (2023)

Transcriptional Upregulation of Plasminogen Activator Inhibitor-1 in Rat Primary Astrocytes by a Proteasomal Inhibitor MG132
por: Cho, Kyu Suk, et al.
Publicado: (2013)

Proteasome Inhibitor MG132 is Toxic and Inhibits the Proliferation of Rat Neural Stem Cells but Increases BDNF Expression to Protect Neurons
por: Kim, Young Min, et al.
Publicado: (2020)

MG-132, an inhibitor of proteasomes and calpains, induced inhibition of oocyte maturation and aneuploidy in mouse oocytes
por: Mailhes, John B, et al.
Publicado: (2002)

PX-12-induced HeLa cell death is associated with oxidative stress and GSH depletion
por: SHIN, HYE RIM, et al.
Publicado: (2013)

Proteasome inhibitor MG132 suppresses pancreatic ductal adenocarcinoma-cell migration by increasing ESE3 expression
por: Jin, Fanjie, et al.
Publicado: (2020)

The Proteasome Inhibitor, MG132, Attenuates Diabetic Nephropathy by Inhibiting SnoN Degradation In Vivo and In Vitro
por: Huang, Wei, et al.
Publicado: (2014)

Proteasome Inhibitor MG132 Enhances Cisplatin-Induced Apoptosis in Osteosarcoma Cells and Inhibits Tumor Growth
por: Sun, Farui, et al.
Publicado: (2018)

Prolonged treatment with the proteasome inhibitor MG-132 induces apoptosis in PC12 rat pheochromocytoma cells
por: Tarjányi, Oktávia, et al.
Publicado: (2022)

An inorganic prodrug, tellurium nanowires with enhanced ROS generation and GSH depletion for selective cancer therapy
por: Wu, Ying, et al.
Publicado: (2019)

Up-regulation of the DR5 Expression by Proteasome Inhibitor MG132 Augments TRAIL-Induced Apoptosis in Soft Tissue Sarcoma Cell Lines
por: Cheong, Hee-Jeong, et al.
Publicado: (2011)

MG132-mediated inhibition of the ubiquitin–proteasome pathway ameliorates cancer cachexia
por: Zhang, Liuping, et al.
Publicado: (2013)

Enhanced efficacy against cervical carcinomas through polymeric micelles physically incorporating the proteasome inhibitor MG132
por: Matsumoto, Yoko, et al.
Publicado: (2016)

MCPIP1 contributes to the toxicity of proteasome inhibitor MG-132 in HeLa cells by the inhibition of NF-κB
por: Skalniak, Lukasz, et al.
Publicado: (2014)

Interplay of Autophagy Inducer Rapamycin and Proteasome Inhibitor MG132 in Reduction of Foam Cell Formation and Inflammatory Cytokine Expression
por: Zhang, Wei, et al.
Publicado: (2018)

Modulatory effect of MG-132 proteasomal inhibition on boar sperm motility during in vitro capacitation
por: Hackerova, Lenka, et al.
Publicado: (2023)

Treatment with the Proteasome Inhibitor MG132 during the End of Oocyte Maturation Improves Oocyte Competence for Development after Fertilization in Cattle
por: You, Jinyoung, et al.
Publicado: (2012)

Proteasome inhibitor MG132 inhibits the proliferation and promotes the cisplatin-induced apoptosis of human esophageal squamous cell carcinoma cells
por: DANG, LIFENG, et al.
Publicado: (2014)

Proteomic Analysis of MG132-Treated Germinating Pollen Reveals Expression Signatures Associated with Proteasome Inhibition
por: Vannini, Candida, et al.
Publicado: (2014)

The proteasome inhibitor MG-132 sensitizes PC-3 prostate cancer cells to ionizing radiation by a DNA-PK-independent mechanism
por: Pajonk, Frank, et al.
Publicado: (2005)

Effect of addition of FSH, LH and proteasome inhibitor MG132 to in vitro maturation medium on the developmental competence of yak (Bos grunniens) oocytes
por: Xiao, Xiao, et al.
Publicado: (2014)

Targeting redox homeostasis in rhabdomyosarcoma cells: GSH-depleting agents enhance auranofin-induced cell death
por: Habermann, Karoline Johanna, et al.
Publicado: (2017)

Blocking Plasmodium falciparum Development via Dual Inhibition of Hemoglobin Degradation and the Ubiquitin Proteasome System by MG132
por: Prasad, Rajesh, et al.
Publicado: (2013)

MG132 protects against lung injury following brain death in rats
por: Shi, Huijuan, et al.
Publicado: (2022)

Sensitization of U937 leukemia cells to doxorubicin by the MG132 proteasome inhibitor induces an increase in apoptosis by suppressing NF-kappa B and mitochondrial membrane potential loss
por: Ortiz-Lazareno, Pablo César, et al.
Publicado: (2014)

Mcl-1 Inhibitor Induces Cells Death in BRAF-Mutant Amelanotic Melanoma Trough GSH Depletion, DNA Damage and Cell Cycle Changes
por: Respondek, Michalina, et al.
Publicado: (2019)

Impact of High Glucose and Proteasome Inhibitor MG132 on Histone H2A and H2B Ubiquitination in Rat Glomerular Mesangial Cells
por: Gao, Chenlin, et al.
Publicado: (2013)

GSH depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer
por: Zhou, Zhanwei, et al.
Publicado: (2020)

Biomimetic CuS nanoparticles for radiosensitization with mild photothermal therapy and GSH-depletion
por: Zhou, Xiaoxiang, et al.
Publicado: (2022)

Proteasome inhibitor (MG132) rescues Na(v)1.5 protein content and the cardiac sodium current in dystrophin-deficient mdx(5cv) mice
por: Rougier, Jean-Sébastien, et al.
Publicado: (2013)

The anti-tumor effect of proteasome inhibitor MG132 for human adenoid cystic carcinoma: correlate with the emerging role of Nrf2/Keap1 signaling pathway
por: Xu, Jiazhi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_mi0j8umgjrqf8boidjea6p8d9e