Inhibition of poly(ADP-ribose) polymerase-1 or poly(ADP-ribose) glycohydrolase individually, but not in combination, leads to improved chemotherapeutic efficacy in HeLa cells

The genome-protecting role of poly(ADP-ribose) (PAR) has identified PAR polymerase-1 (PARP-1) and PAR glycohydrolase (PARG), two enzymes responsible for the synthesis and hydrolysis of PAR, as chemotherapeutic targets. Each has been previously individually evaluated in chemotherapy, but the effects...

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Detalles Bibliográficos
Autores principales: FENG, XIAOXING, KOH, DAVID W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583631/
https://www.ncbi.nlm.nih.gov/pubmed/23254695
http://dx.doi.org/10.3892/ijo.2012.1740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583631/
https://www.ncbi.nlm.nih.gov/pubmed/23254695
http://dx.doi.org/10.3892/ijo.2012.1740

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