COPII machinery cooperates with ER-localized Hsp40 to sequester misfolded membrane proteins into ER-associated compartments

Proteins that fail to fold in the endoplasmic reticulum (ER) are subjected to ER-associated degradation (ERAD). Certain transmembrane ERAD substrates are segregated into specialized ER subdomains, termed ER-associated compartments (ERACs), before targeting to ubiquitin–proteasome degradation. The tr...

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Detalles Bibliográficos
Autores principales: Kakoi, Shogo, Yorimitsu, Tomohiro, Sato, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583666/
https://www.ncbi.nlm.nih.gov/pubmed/23303252
http://dx.doi.org/10.1091/mbc.E12-08-0639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583666/
https://www.ncbi.nlm.nih.gov/pubmed/23303252
http://dx.doi.org/10.1091/mbc.E12-08-0639

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