Targeted inhibition of heat shock protein 90 disrupts multiple oncogenic signaling pathways, thus inducing cell cycle arrest and programmed cell death in human urinary bladder cancer cell lines

BACKGROUND: Geldanamycin (GA) can be considered a relatively new component with a promising mode of action against human malignancies. It specifically targets heat shock protein 90 (Hsp90) and interferes with its function as a molecular chaperone. METHODS: In this study, we have investigated the eff...

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Detalles Bibliográficos
Autores principales: Karkoulis, Panagiotis K, Stravopodis, Dimitrios J, Konstantakou, Eumorphia G, Voutsinas, Gerassimos E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583703/
https://www.ncbi.nlm.nih.gov/pubmed/23394616
http://dx.doi.org/10.1186/1475-2867-13-11

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583703/
https://www.ncbi.nlm.nih.gov/pubmed/23394616
http://dx.doi.org/10.1186/1475-2867-13-11

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