Correlation of MLH1 and MGMT expression and promoter methylation with genomic instability in patients with thyroid carcinoma

BACKGROUND: Gene silencing of the repair genes MLH1 and MGMT was shown to be a mechanism underlying the development of microsatellite instability (MSI), a phenotype frequently associated with various human malignancies. Recently, aberrant methylation of MLH1, MGMT and MSI were shown to be associated...

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Detalles Bibliográficos
Autores principales: Santos, Juliana Carvalho, Bastos, André Uchimura, Cerutti, Janete Maria, Ribeiro, Marcelo Lima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583824/
https://www.ncbi.nlm.nih.gov/pubmed/23414134
http://dx.doi.org/10.1186/1471-2407-13-79

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583824/
https://www.ncbi.nlm.nih.gov/pubmed/23414134
http://dx.doi.org/10.1186/1471-2407-13-79

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