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Correlation of MLH1 and MGMT expression and promoter methylation with genomic instability in patients with thyroid carcinoma
BACKGROUND: Gene silencing of the repair genes MLH1 and MGMT was shown to be a mechanism underlying the development of microsatellite instability (MSI), a phenotype frequently associated with various human malignancies. Recently, aberrant methylation of MLH1, MGMT and MSI were shown to be associated...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583824/ https://www.ncbi.nlm.nih.gov/pubmed/23414134 http://dx.doi.org/10.1186/1471-2407-13-79 |