Specific temperature-induced perturbations of secondary mRNA structures are associated with the cold-adapted temperature-sensitive phenotype of influenza A virus

For decades, cold-adapted, temperature-sensitive (ca/ts) strains of influenza A virus have been used as live attenuated vaccines. Due to their great public health importance it is crucial to understand the molecular mechanism(s) of cold adaptation and temperature sensitivity that are currently unkno...

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Detalles Bibliográficos
Autores principales: Chursov, Andrey, Kopetzky, Sebastian J., Leshchiner, Ignaty, Kondofersky, Ivan, Theis, Fabian J., Frishman, Dmitrij, Shneider, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583857/
https://www.ncbi.nlm.nih.gov/pubmed/22995831
http://dx.doi.org/10.4161/rna.22081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583857/
https://www.ncbi.nlm.nih.gov/pubmed/22995831
http://dx.doi.org/10.4161/rna.22081

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