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Established breast cancer stem cell markers do not correlate with in vivo tumorigenicity of tumor-initiating cells

The tumor-initiating capacity of primary human breast cancer cells is maintained in vitro by culturing these cells as spheres/aggregates. Inoculation of small cell numbers derived from these non-adherent cultures leads to rapid xenograft tumor formation in mice. Accordingly, injection of more differ...

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Detalles Bibliográficos
Autores principales: LEHMANN, CHRISTIAN, JOBS, GABRIELE, THOMAS, MARKUS, BURTSCHER, HELMUT, KUBBIES, MANFRED
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583871/
https://www.ncbi.nlm.nih.gov/pubmed/23042145
http://dx.doi.org/10.3892/ijo.2012.1654