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The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors
We have recently reported that lowering the pH to values that are frequently detected in tumors causes reversible anergy in both human and mouse CD8(+) T lymphocytes in vitro. The same occurs in vivo, in the tumor microenvironment and the administration of proton pump inhibitors, which buffer tumor...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583905/ https://www.ncbi.nlm.nih.gov/pubmed/23483769 http://dx.doi.org/10.4161/onci.22058 |